ANTIHYPERGLYCEMIC OF OLIVE LEAF (OLEA EUROPAEA L.) ETHANOL EXTRACT IN OBESITY DIABETIC MALE MICE (MUS MUSCULUS)

Olive leaf (Olea europeae) contains the primary polyphenols: oleuropein, hydroxytyrosol, luteolin 7- glucoside, apigenin 7-glucoside, and verbascoside. Empirically olive leaf is used for lowering blood sugar because it has antioxidant properties. This study aimed to determine the antihyperglycemic activity of olive leaf ethanol extract in obese male mice. This study was conducted by measuring fasting blood sugar by pre and post-administration of olive leaf ethanol extract. The method used in this study was the administration of a high-fat diet for six weeks and the alloxan induction method. The test group was divided into four groups (mg/KgBW) consisting of a control group (diabetic control and metformin 500) and group treatments of olive leaf extract (225 and 400). Each group consisting of five mice. Data analysis using Minitab 19. The results showed that there was an average difference between pre and post (mg/dL) in each group (P-Value <0.05) were BC (139.80±10.35) and (151.80±21.36), metformin (152.20±14.06) and (75.40±20.48), EOD 225 (157.80±16.90) and (99.20±30.60), EOD 400 (178.20± 35.10) and (80.60±20.79). It can be concluded that the ethanolic extract of olive leaf (Olea Europaea L.) in the treatment group can reduce fasting blood glucose levels of alloxan-induced obese male mice.